Prognostic effects of clinical and CT imaging features on critically ill patients with interstitial lung disease hospitalized in respiratory intensive care unit
Identifieur interne : 000515 ( Main/Exploration ); précédent : 000514; suivant : 000516Prognostic effects of clinical and CT imaging features on critically ill patients with interstitial lung disease hospitalized in respiratory intensive care unit
Auteurs : Shenyun Shi ; Yonglong Xiao ; Xiaohua Qiu ; Yan Li ; Yuying Qiu ; Kefeng Zhou ; Hourong CaiSource :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
The study aimed to evaluate the clinical and imaging features of critically ill patients with interstitial lung disease (ILD) treated in respiratory intensive care unit (RICU) and assess the prognostic effects of these factors. A total of 160 severe ILD patients admitted to the RICU were finally enrolled in this study. The clinical, imaging and follow-up data of them were studied retrospectively. The in-hospital mortality and total mortality were 43.1% and 63.8% respectively. By multivariate cox regression analysis, shock (OR = 2.39, P = 0.004), pulmonary fibrosis on CT (OR = 2.85, P = 0.002) and non-invasive ventilation (OR = 1.86, P = 0.037) were harmful factors to survivals of critically ill patients with ILD. In contrast, oxygenation index (OR = 0.99, P = 0.028), conventional oxygen therapy (OR = 0.59, P = 0.048) and β-lactam antibiotics use (OR = 0.51, P = 0.004) were protective factors. There is significant difference of survivals between patients with and without fibrosing ILD on CT (Log-rank, p = 0.001). The prognosis of critically ill patients with ILD was poor. Shock, respiratory failure and fibrosing signs on chest CT affected the prognosis. Chest CT was considered as a valuable tool to indicate the prognosis.
Url:
DOI: 10.1038/s41598-019-53865-0
PubMed: 31748613
PubMed Central: 6868154
Affiliations:
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sortKey="Shi, Shenyun" sort="Shi, Shenyun" uniqKey="Shi S" first="Shenyun" last="Shi">Shenyun Shi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Department of Respiratory Medicine, Nanjing Drum Tower Hospital,</institution><institution>Clinical College of Nanjing Medical University,</institution></institution-wrap>Nanjing, 210008 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210008 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Xiao, Yonglong" sort="Xiao, Yonglong" uniqKey="Xiao Y" first="Yonglong" last="Xiao">Yonglong Xiao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1800 1685</institution-id><institution-id institution-id-type="GRID">grid.428392.6</institution-id><institution>Department of Respiratory 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institution-id-type="ISNI">0000 0004 1800 1685</institution-id><institution-id institution-id-type="GRID">grid.428392.6</institution-id><institution>Department of Respiratory Medicine,</institution><institution>Nanjing Drum Tower Hospital, Nanjing University Medical School,</institution></institution-wrap>Nanjing, 210008 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210008 Jiangsu China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The study aimed to evaluate the clinical and imaging features of critically ill patients with interstitial lung disease (ILD) treated in respiratory intensive care unit (RICU) and assess the prognostic effects of these factors. A total of 160 severe ILD patients admitted to the RICU were finally enrolled in this study. The clinical, imaging and follow-up data of them were studied retrospectively. The in-hospital mortality and total mortality were 43.1% and 63.8% respectively. By multivariate cox regression analysis, shock (OR = 2.39, P = 0.004), pulmonary fibrosis on CT (OR = 2.85, P = 0.002) and non-invasive ventilation (OR = 1.86, P = 0.037) were harmful factors to survivals of critically ill patients with ILD. In contrast, oxygenation index (OR = 0.99, P = 0.028), conventional oxygen therapy (OR = 0.59, P = 0.048) and β-lactam antibiotics use (OR = 0.51, P = 0.004) were protective factors. There is significant difference of survivals between patients with and without fibrosing ILD on CT (Log-rank, p = 0.001). The prognosis of critically ill patients with ILD was poor. Shock, respiratory failure and fibrosing signs on chest CT affected the prognosis. Chest CT was considered as a valuable tool to indicate the prognosis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zafrani, L" uniqKey="Zafrani L">L Zafrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gannon, Wd" uniqKey="Gannon W">WD Gannon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradley, B" uniqKey="Bradley B">B Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Travis, Wd" uniqKey="Travis W">WD Travis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansell, Dm" uniqKey="Hansell D">DM Hansell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akira, M" uniqKey="Akira M">M Akira</name></author><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y Inoue</name></author><author><name sortKey="Arai, T" uniqKey="Arai T">T Arai</name></author><author><name sortKey="Okuma, T" uniqKey="Okuma T">T Okuma</name></author><author><name sortKey="Kawata, Y" uniqKey="Kawata Y">Y Kawata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silva, Cis" uniqKey="Silva C">CIS Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosaka, J" uniqKey="Kosaka J">J Kosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotani, T" uniqKey="Kotani T">T Kotani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gungor, G" uniqKey="Gungor G">G Gungor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaudry, S" uniqKey="Gaudry S">S Gaudry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mollica, C" uniqKey="Mollica C">C Mollica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oda, K" uniqKey="Oda K">K Oda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawamura, K" uniqKey="Kawamura K">K Kawamura</name></author><author><name sortKey="Ichikado, K" uniqKey="Ichikado K">K Ichikado</name></author><author><name sortKey="Suga, M" uniqKey="Suga M">M Suga</name></author><author><name sortKey="Yoshioka, M" uniqKey="Yoshioka M">M Yoshioka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oikonomou, A" uniqKey="Oikonomou A">A Oikonomou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debray, Mp" uniqKey="Debray M">MP Debray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Juhl, Ks" uniqKey="Juhl K">KS Juhl</name></author><author><name sortKey="Bendstrup, E" uniqKey="Bendstrup E">E Bendstrup</name></author><author><name sortKey="Rasmussen, F" uniqKey="Rasmussen F">F Rasmussen</name></author><author><name sortKey="Hilberg, O" uniqKey="Hilberg O">O Hilberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichikado, K" uniqKey="Ichikado K">K Ichikado</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cai, Hourong" sort="Cai, Hourong" uniqKey="Cai H" first="Hourong" last="Cai">Hourong Cai</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Qiu, Xiaohua" sort="Qiu, Xiaohua" uniqKey="Qiu X" first="Xiaohua" last="Qiu">Xiaohua Qiu</name><name sortKey="Qiu, Yuying" sort="Qiu, Yuying" uniqKey="Qiu Y" first="Yuying" last="Qiu">Yuying Qiu</name><name sortKey="Shi, Shenyun" sort="Shi, Shenyun" uniqKey="Shi S" first="Shenyun" last="Shi">Shenyun Shi</name><name sortKey="Xiao, Yonglong" sort="Xiao, Yonglong" uniqKey="Xiao Y" first="Yonglong" last="Xiao">Yonglong Xiao</name><name sortKey="Zhou, Kefeng" sort="Zhou, Kefeng" uniqKey="Zhou K" first="Kefeng" last="Zhou">Kefeng Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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